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Category:Point of sale softwarePositive selection in HIV-1, 2, and 6 sequences. To investigate the evolutionary pattern of HIV sequences, we have reconstructed a phylogenetic tree of HIV sequences from the IAS (International AIDS Society) Data Set. When we analyze the present-day HIV sequences, we observe one dominant variant with numerous subpopulations consisting of many strains. Based on the small-world hypothesis, we infer that the generation of HIV sequences is governed by a stochastic process in which two sequences come into contact due to their close geographical locations. We show that the probability of a single sequence changing into a new dominant sequence under these conditions is high. A plausible explanation for the persistence of the dominant HIV sequence is that the HIV sequence is positively selected. Such a process favors the generation of sequences with certain properties, including a high rate of replication, and a low rate of mutation and deletions. In this study, we show that for a given collection of HIV sequences from different hosts, the HIV sequences are not selected randomly but with a certain bias.Association of genetic polymorphism of the angiotensin-converting enzyme gene with hypertension. The role of the angiotensin-converting enzyme (ACE) gene in the pathogenesis of hypertension is not known. We performed a case-control study to evaluate the role of the ACE gene on blood pressure (BP) levels in normotensive and hypertensive humans. A sample of 197 individuals, including 37 subjects with essential hypertension and 160 normotensive individuals, was studied. The ACE genotype was assessed by amplification of the ACE gene polymorphism in the presence of RsaI (plasma renin activity) and NlaIII restriction sites, by using a polymerase chain reaction (PCR) method. The frequencies of the ACE I/D polymorphism in hypertensive and normotensive individuals were 52.7% and 57.5%, respectively. The presence of D allele was associated with a higher systolic BP level (p = 0.04), with a higher frequency in male (p = 0.02) and white (p = 0.05) subjects, and with the presence of diabetes mellitus (p = 0.03). These associations were not observed in normotensive individuals. This study, in a sample of 97% Caucasians, showed an association of the ACE I/D polymorphism with BP levels in hypertensive subjects. In the presence of diabetes mellitus, the association with the

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